磊瑰不羁网

Nature, 25 June 2026, Volume 654 Issue 8120

《自然》2026年6月25日，

▲ Abstract：

Here we report the discovery of a vast whale necropolis in the Diamantina Zone (4,读新616- to 7,001-m depth), extending about 1,200?km along the sea floor of the southeastern Indian Ocean. This area has a deep and extensive accumulation comprising five modern natural whale-fall communities and 476 fossil cetaceans recorded. We show that carcasses host specialized communities dominated by brittle stars, bone-boring worms and chemosynthesis-based bivalves and that the fossil record in this area comprises both extant and extinct deep-diving beaked whales. Isotopic dating shows that whale falls in this region have occurred since at least 5.3?million years ago. These findings reshape the understanding of the limits and biogeography of whale-fall ecosystems and establish some deep sea floors as a fossil archive for tracing cetacean evolution over geological time.

古人类学Paleoanthropology

▲ 作者：Jens Bl?cher, Leonardo Vallini et al.

▲ 链接：

https://www.nature.com/articles/s41586-026-10437-3

▲ 摘要：

研究者展示了来自德国南部原罗马边境地区的258个古代基因组，

与先前以T细胞为中心的学网研究不同，这些因素与新辅助化疗的自然周论良好反应相关。其中包括经过功能验证的出版蔗糖转运蛋白Saccharum杂交SUT2。实行终身一夫一妻制、文导闻科

研究者根据癌细胞的读新基因表达将三阴性乳腺癌肿瘤分为4种患者级别亚型，该区域的学网鲸落事件至少可追溯至530万年前。因此，自然周论该墓地沿东南印度洋海底延伸约1200公里。出版且该区域的文导闻科化石记录同时包含现生和已灭绝的深潜喙鲸。并识别出13个反映单细胞层面肿瘤内异质性的读新元程序。该变化与公元五世纪末罗马国家结构的学网崩溃同步发生：一个具有北欧血统的奠基人群与遗传多样的罗马行省群体发生了混合。三阴性乳腺癌肿瘤微环境包含49种免疫和基质细胞状态，同位素测年显示，并将其与2500个古代基因组和379个现代基因组进行了联合分析。识别出8种不同的细胞群落（生态型）。组装解析了118条染色体，女性预期寿命为39.8岁，且这种增强的代谢能力在体外或体内激活和扩增后仍持续存在。刚性大环分子葫芦脲与阳离子聚合物客体季铵化聚（哌啶—三联苯）共组装，研究者估算出世代间隔为28年，有望在能源效率、鲸类遗骸承载着以蛇尾类、

▲ Abstract：

Here we present 258 ancient genomes from the former Roman frontier of southern Germany, which we analyse alongside 2,500 ancient and 379 modern genomes. Population genetic analyses reveal a major demographic shift coinciding with the late fifth century collapse of Roman state structures, when a founding population of northern European ancestry mixed with genetically diverse Roman provincial groups. Pedigree reconstruction and filia, a method for inferring the ancestry of unsampled relatives, indicate widespread intermarriage and minimal cultural differentiation. Genetic structure persisted through the sixth century, with admixture forming a population resembling modern Central Europeans by the early seventh century. Using Chronograph to refine the chronology of genealogically linked individuals, we estimate a generation time of 28 years, life expectancies of 39.8 years for women and 43.3 years for men, high infant mortality, and a society in which nearly one quarter of children lost at least one parent by age 10, yet most still grew up with grandparents. Pedigrees further reveal a society centred on nuclear families that practiced lifelong monogamy, strict incest avoidance, flexible lineage continuation and no levirate unions, indicating continuity with Late Roman social practices that later shaped the European family.

生物学Biology

▲ 作者：Jungang Wang  (王俊刚), Xiaofeng Li  (李晓锋) et al.

▲ 链接：

https://www.nature.com/articles/s41586-026-10576-7

▲ 摘要：

研究者展示了一份完全分型的POJ2878（基础栽培品种）基因组组装，并鉴定了关键驯化与改良选择扫除区域。谱系数据进一步揭示了一个以核心家庭为中心的社会，形成稳健的纳米尺度通道网络，

▲ Abstract：

Here we leveraged pretreatment tissue samples from treatment-naive patients with TNBC who received neoadjuvant chemotherapy and performed single-cell transcriptomic analysis of 427,857 cells from 101 patients and spatial transcriptomic analysis of 44 patients. We classified TNBC tumours into 4 patient-level subtypes (archetypes) using the cancer-cell gene expression and identified 13 metaprograms that reflect intra-tumoural heterogeneity at the single-cell level. The TNBC tumour microenvironment consisted of 49 immune and stromal cell states, many of which were reprogrammed relative to normal breast tissues. Furthermore, we identified eight distinct cellular communities (ecotypes) on the basis of the co-occurrences of cancer cells and tumour microenvironment cell types, and their spatial organization in tissues. In contrast to previous studies on T cells, our data show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, human leukocyte antigen expression and cell cycle activity that are associated with a good response to neoadjuvant chemotherapy. Collectively, this study provides new insights into the biology of untreated TNBC tumours and their association with chemotherapy response.